proteasome inhibitor-1 — TargetMol Chemicals

Cat No.	Product Name	Synonyms	Targets
T8978	DD1	3,3'-Diamino-4'-methoxyflavone,HUN85111	Proteasome
	DD1 (HUN85111) is a proteasome inhibitor that induces human myeloid tumor-selective apoptosis.		Proteasome
T13273	UT-34		Androgen Receptor
	UT-34 is a selective and orally active antagonist of second-generation pan-androgen receptor (AR) and degrader(IC50s of 211.7 nM, 262.4 nM and 215.7 nM for wild-type, F876L and W741L AR, respectively), and has anti-prost...		Androgen Receptor
T6583	MG-101	ALLN,Ac-LLnL-CHO,Calpain inhibitor I,Calpain inhibitor-1,MG101	Cysteine Protease , Proteasome
	MG-101 (Calpain inhibitor I) is a cell-permeable and potent inhibitor of cysteine proteases including calpains and lysosomal cathepsins.		Cysteine Protease , Proteasome
T10765	Eragidomide	CC-90009,Cereblon modulator 1	Apoptosis , Ligand for E3 Ligase , Molecular Glues
	Eragidomide (CC-90009; Cereblon modulator 1) is a cereblon (CRBN) E3 ligase modulator. Eragidomide specifically binds to CRBN, thereby affecting the activity of the ubiquitin E3 ligase complex.		Apoptosis , Ligand for E3 Ligase , Molecular Glues
T8745	PROTAC BRAF-V600E degrader-1	Compound 23	Raf
	PROTAC BRAF-V600E degrader-1 (Compound 23) selectively induces degradation of BRAF-V600E but not wildtype BRAF.		Raf
T21510	PSI		Proteasome
	PSI is a proteasome inhibitor.		Proteasome
T12628	(R)-MG-132	(S,R,S)-(-)-MG-132,Z-Leu-D-leu-leu-al	Proteasome
	(R)-MG-132 (Z-Leu-D-leu-leu-al) is the enantiomer of MG-132. (R)-MG-132 stereoisomer is a more potent proteasome inhibitor than MG-132.		Proteasome
T21854	Proteasome inhibitor IX	PS-IX,AM114	Proteasome
	Proteasome inhibitor IX (PS-IX) is an inhibitor of chymotrypsin-like activity of the 20S proteasome (IC50 ~1 μM). Proteasome inhibitor IX shows potent anticancer activity. Proteasome inhibitor IX exhibits HCT116 p53+/+ c...		Proteasome
T21617	MG-115	Z-LL-Nva-CHO	Proteasome
	MG-115 (Z-LL-Nva-CHO) is a potent and reversible inhibitor of proteasome , with K i s of 21 nM and 35 nM for 20S and 26S proteasome, respectively. MG-115 specifically inhibit the chymotrypsin-like activity of the proteas...		Proteasome
T7016	VR23		Apoptosis , Proteasome , Caspase
	VR23 is a potent proteasome inhibitor. Data shows IC50 =1 nM for trypsin-like proteasomes, IC50=50-100 nM for chymotrypsin-like proteasomes, and IC50=3 μM for caspase-like proteasomes.		Apoptosis , Proteasome , Caspase
T6029	ONX-0914	ONX0914,PR-957,ONX 0914	Proteasome , HIV Protease , Antibacterial
	ONX-0914 (PR-957) is an effective and specific immunoproteasome inhibitor, which has minimal cross-reactivity for the constitutive proteasome.		Proteasome , HIV Protease , Antibacterial
T77620	LMTK3-IN-1		c-Met/HGFR
	Lmtk3-in-1 is a potent ATP-competitive lemur tyrosine kinase 3 (LMTK3) (Kd=2.5 μM) inhibitor that degrades LMTK3 through the ubiquitin proteasome pathway. LMTK3-IN-1 has shown anticancer activity in a variety of cancer c...		c-Met/HGFR
T12561	Proteasome-IN-1		Proteasome
	Proteasome-IN-1 is an inhibitor of proteasome.		Proteasome
T16795	Rpn11-IN-1	Capzimin intermediate	Others
	Rpn11-IN-1 is an effective and selective inhibitor of proteasome subunit Rpn11 (IC50: 390 nM).		Others
T81371	Proteasome-IN-5		Proteasome
	Proteasome-IN-5, also known as compound 5, acts as a proteasome inhibitor [1].		Proteasome
T81373	Proteasome β2c/i-IN-1		Proteasome
	Proteasome β2c/i-IN-1 (compound 37) serves as a selective inhibitor targeting the β2c and β2i subunits of the human proteasome [1].		Proteasome
T79842	Davelizomib		Proteasome
	Davelizomib is a proteasome inhibitor that exhibits antineoplastic activity [1].		Proteasome
T21968	MG-262
	MG-262 is a reversible proteasome inhibitor with multiple biological activities [1] [2] [3].
T75623	Sadopeptins A
	Sadopeptins A, a natural product isolated from Streptomyces sp., is a potent proteasome inhibitor [1].
T62255	20S Proteasome-IN-4
	20S Proteasome-IN-4 (Compound 7) is an orally active inhibitor of the 20S proteasome, selectively targeting the parasite form and demonstrating brain penetration capabilities. It exhibits a potent IC50 value of 6.3 nM ag...